A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.
Methods:
15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW.
Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer’s software.
Results:
GET was significantly faster after erythromycin than either saline or morphine.
Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance.
Conclusions:
A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine.
These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
Author: Inna Rozov-UngAmjad MreyoudJohn MooreGregory E WildingElias KhawamJeffrey M LacknerJohn R SemlerMichael D Sitrin
Credits/Source: BMC Gastroenterology 2014, 14:2
Published on: 2014-01-03
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News Provider: EUPB – European Press Bureau
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