Dec. 26, 2012 ? Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose categorical duty is to say corneal clarity by controlling corneal hydration. Cell detriment due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, ensuing in a need for cornea transplants.
Studying tellurian corneal endothelium has been formidable for dungeon biologists since singular mobile indication systems exist and have poignant drawbacks. The vital obstacle is that HCEnC cells do not order and there is a singular source of these cells both for studious transplantation and for investigate in a laboratory. This margin of investigate is now easier.
Scientists from a Schepens Eye Research Institute, Mass. Eye and Ear, have grown of HCENC-21 and HCEnC-21T, dual novel indication systems for tellurian corneal endothelium. Their findings, “Telomerase Immortalization of Human Corneal Endothelial Cells Yield Functional Hexagonal Monolayers,” are online in a PLOS ONE.
A investigate group led by Ula Jurkunas, M.D., grown first-of their kind indication systems for tellurian corneal endothelium.
“These models impersonate really good a vicious characteristics and functionalities famous from a hankie in a eye,” Dr. Jurkunas said. “They also perform essential technical requirements, e.g. unfixed series of and a high rate of dungeon division, to be a absolute tool. They will capacitate dungeon biologists to some-more reliably investigate tellurian corneal endothelium in health and disease. The ability to raise HCEnC dungeon self renovation and expansion opens a new window of growth of novel regenerative therapies for corneal swelling, hopefully shortening a need for corneal transplantation in a future.”
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The above story is reprinted from materials supposing by Massachusetts Eye and Ear Infirmary.
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Journal Reference:
- Thore Schmedt, Yuming Chen, Tracy T. Nguyen, Shimin Li, Joseph A. Bonanno, Ula V. Jurkunas. Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers. PLoS ONE, 2012; 7 (12): e51427 DOI: 10.1371/journal.pone.0051427
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