healthmedicinet

Alitretinoin is a vitamin A derivative. It’s a pan-agonist of Retinoic Acid Receptors
and Retinoid X Receptors. It interferes with keratinocytes’ proliferation and differentiation
and exerts immunomodulatory and anti-inflammatory activity. Its clinical efficacy
in the treatment of chronic hand eczema is well demonstrated. Recently, various case
reports and case series pointed out its efficacy in other skin inflammatory disorders
such as atopic dermatitis, psoriasis, lichen planus, Darier’s disease, Hailey Hailey’s
disease, lichen simplex, pityriasis rubra pilaris and cutaneous lupus erythematosus.