Do you know: Why can antibiotics even fail against non-resistant bacteria
Antibiotics are essential to treat bacterial infections. But why are they sometimes ineffective, even when the bacteria are not resistant? In his latest study published in the magazine Nature, Researchers from the University of Basel challenge the normal view that a small sub -record of extremely resilient bacteria is responsible for the failure of antibiotic therapies.
In certain infectious humans due to bacteria, antibiotics are not as effective as expected. One example is infections due to Salmonella Bacteria, which can lead to illness fever. For many years, researchers believed that the main problem for combating infections was a small sub -pocket of idle bacteria. These so -called persisters can live with antibiotic and relapse treatment later. Researchers around the world are working on new therapies aimed at focusing and eliminating these “sleep” bacteria.
In a new study, Professor Dirk Bann from Bio -Basel University’s Aimmation is challenged for the prevailing concept that persisters are a cause of antibiotic inefficiencies. “Unlike widespread belief, a small fotchair of persisters does not lead to antibiotic failure. In fact, most of Salmonella In infected tissues it is difficult to kill, “explains Bumann.” We were able to demonstrate that standard laboratory tests on antimicrobial clearance produces misleading results, giving a false insight into a small group of resilient mash. “
Nutrient hunger increases Salmonella resilience
The researchers investigated an antimicrobial clearance in both Salmonella-Mice laboratory models and tissue tissue. The body’s protection mechanisms against bacteria often include reducing nutrients. The researchers have now shown that this nutrient hunger is the main cause of Salmonella Bacteria that live treatments with antibiotics. The researchers accept that the same applies to other bacterial pathogens.
“Under nutrient nutrient conditions, bacteria grow very slowly,” says Bumann. “This may be good at first, but it is really a problem because most of the antibiotics do not gradually grow bacteria.” As a result, these drugs are much more effective, and re -turning can occur even after long therapy.
Real-time analyzes show a misunderstanding
Scientists used an innovative method of monitoring antibiotic action in individual bacteria in Fig. “We showed that almost the whole is all Salmonella The antibiotic treatment population lasts for stretched periods, not only a small subset of hyper-resilient persisters, “says Dr. Joseph Fanous, the first author of the study.
Their indirect measurement and delayed bacterial survival are a major issue with the standard methods used worldwide for years. “The traditional tests are underestimated on the number of bacteria,” explains it. “And they falsely recommend that hyper-resilients of persisters are not really there.” This misunderstanding has affected research for many years.
Novel tools for antibiotic research
These results could essentially change antibiotic research. “Our work emphasizes the importance of the study of bacterial behavior and live antibiotic effects and physiological relevant conditions,” which emphasizes Bumann. “In a few years, it is expected that modern methods such as real-time single cell analysis.” An important step towards more effective therapies against infections is difficult to treat the focus from persisters to the impact of nutritional hunger.
The project is part of the National Competency Center in Research (NCCR) “Antiresist.” The research consortium aims to develop innovative strategies to tackle bacterial infections. Dirk Bann is one of the directors of the NCCR “Antiresist.”
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