Research points to an immunotherapy to overcome resistant leukemia
HMN 2024 – TP53 deficiency in AML leads to resistance against CAR T-cell-mediated killing that can be overcome by targeting the mevalonate and Wnt pathways. Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-024-00024-2 Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of […]