Scientists identify new treatment target for leading cause of blindness

Schematic diagram illustrating the role of ADORA2A-mediated SDHB-succinate signaling in EndMT and the subsequent subretinal fibrosis. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adk3868 Medical College of Georgia scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don’t benefit from the most used therapy for neovascular age-related macular degeneration (AMD), a leading cause of blindness. AMD is a condition characterized by abnormal blood vessel growth in the back of the eye. It is highly prevalent in Read More