Successful murine model of dermatomyositis reveals underlying immune system involvement
HMN 2024 – Autoimmunity to MDA5, CD4 T cells reactive MDA5, works as ‘Seed’, and inducible factors like as virus infection and poly (I:C) treatment induce type I IFN upregulation and MDA5 expression on the lung and works as ‘Soil’. The seed and soil work together to establish interstitial lung disease. IL-6 mediates lung fibrosis. Credit: Department of […]