Jan. 4, 2013 ? The prolongation of new neurons in a adult normal cortex in response to a antidepressant, fluoxetine, is reported in a investigate published online this week in Neuropsychopharmacology.
The investigate team, that is formed during a Institute for Comprehensive Medical Science, Fujita Health University, Aichi, has formerly demonstrated that neural progenitor cells exist during a aspect of a adult cortex, and, moreover, that ischemia enhances a era of new inhibitory neurons from these neural progenitor cells. These cells were accordingly named “Layer 1 Inhibitory Neuron Progenitor cells” (L1-INP). However, until now it was not famous either L1-INP-related neurogenesis could be prompted in a normal adult cortex.
Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a resourceful serotonin reuptake inhibitor, and one of a many widely used antidepressants, to kindle a prolongation of new neurons from L1-INP cells. A vast commission of these newly generated neurons were inhibitory GABAergic interneurons, and their era coincided with a rebate in apoptotic dungeon genocide following ischemia. This anticipating highlights a intensity neuroprotective response prompted by this calmative drug. It also lends serve support to a postulation that initiation of adult neurogenesis in cortex is a applicable prevention/treatment choice for neurodegenerative diseases and psychiatric disorders.
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Journal Reference:
- Koji Ohira, Rika Takeuchi, Hirotaka Shoji and Tsuyoshi Miyakawa. Fluoxetine-Induced Cortical Adult Neurogenesis Open. Neuropsychopharmacology, 2013 DOI: 10.1038/npp.2013.2
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Source: Health Medicine Network