Jan. 17, 2013 ? A investigate in The Journal of General Physiology examines a consequences of flesh activity with startling results, indicating that a extracellular accumulation of potassium that occurs in operative muscles is extremely aloft than formerly thought.
Muscle excitation involves a liquid of sodium ions and exhalation of potassium ions. Although a fragment of ions that cranky a flesh surface with any contraction is minute, steady activity can lead to estimable changes in a intracellular and extracellular concentrations of sodium and potassium ions. The border of these changes, however, has been unclear. Now, Torben Clausen from Aarhus University in Denmark provides quantitative analyses of a changes in intracellular and extracellular ion thoroughness ensuing from kick of a leg flesh in rats, providing discernment into how they change with flesh activity.
Clausen totalled a changes in thoroughness of sodium, potassium, and chloride ions in operative rodent extensor digitorum longus (ESL) muscles. Remarkably, when their muscles were wild to glow during a rate of 5 Hz (comparable to that in a legs of a chairman roving a bicycle) for 5 minutes, sufficient intracellular potassium was mislaid to lead to an extracellular thoroughness that would meddle with serve excitation. These formula advise that accumulation of extracellular potassium is a most incomparable writer to flesh tired than formerly thought, that might be of sold significance in such conditions as hyperkalemic periodic stoppage and other channelopathies that impact fundamental muscle.
These changes in ion placement are against by a movement of a “Na+/K+ pump†— that expends appetite to pierce sodium out of a dungeon and potassium into it — and will therefore be even some-more conspicuous underneath disease- and injury-related conditions compared with decreased siphon activity.
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The above story is reprinted from materials supposing by Rockefeller University Press, around EurekAlert!, a use of AAAS.
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Journal Reference:
- T. Clausen. Excitation-induced sell of Na , K , and Cl- in rodent EDL flesh in vitro and in vivo: Physiology and pathophysiology. The Journal of General Physiology, 2013; DOI: 10.1085/jgp.201210892
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