Many patients with gastric gastrointestinal stromal tumor (GIST) and synchronous gastric cancer have been described, most in single case studies. We retrospectively investigated the clinicopathologic features and prognostic effects of gastric GIST in patients with synchronous gastric cancer.
Methods:
The study enrolled 170 patients with gastric GIST, who had undergone complete surgical resection (R0) from January 2000 to December 2011.
Forty-two patients had synchronous gastric cancer (CA Group), whereas 128 did not (Non-CA Group). The clinicopathologic features and potential prognostic factors in the two groups were compared.
Results:
Patients in the CA Group had more obvious symptoms, but a lower rate of preoperative diagnosis of gastric GIST (P
The two groups differed significantly in gender, age, greatest tumor diameter, risk stratification, tumor-associated ulcers, and CD117 and CD34 expression (P
Cox regression analysis showed that risk stratification, postoperative oral imatinib and synchronous gastric cancer were independent predictors of survival (P
Conclusions:
Gastric GIST with synchronous gastric cancer had a lower rate of preoperative diagnosis, with correct diagnosis often missed.
Survival, however, depended primarily on the gastric cancer.
Author: Mi LinJian-Xian LinChang-Ming HuangChao-Hui ZhengPing LiJian-Wei XieJia-Bin WangJun Lu
Credits/Source: World Journal of Surgical Oncology 2014, 12:25
Published on: 2014-01-31
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