The protein sTREM2 plays a crucial role in Alzheimer’s disease, but the role is complex and poorly understood. In the early stages of the disease, sTREM2 levels in the cerebrospinal fluid fall relative to healthy people’s, but then the levels rise far above normal as the disease progresses. Why the levels fluctuate and whether the fluctuations reflect or cause disease progression is unknown. In a study published in the journal Molecular Neurodegeneration, Carlos Cruchaga, the Barbara Burton & Reuben Morriss III Professor of Psychiatry at the School of Medicine, and Read More