Children genetically prone to cancer benefit from early standardized surveillance

Recent advances in genomic sequencing have revealed that 5–15% of children with cancer have an underlying genetic predisposition. Although genetic predispositions increase the risk for new tumors, it has been unclear when to begin surveillance for these tumors. St. Jude Children’s Research Hospital scientists showed that beginning surveillance soon after recognizing a patient’s predisposition often led to discovering one or more early-stage asymptomatic tumors. About half of these tumors could be completely removed by surgery alone, thus avoiding the need for toxic chemotherapies or radiation therapies. The findings inform clinical Read More

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