New discovery could help treat a rare and severe form of amyloidosis

PET scan of a human brain with Alzheimer’s disease. Credit: public domain In people with a rare condition called light chain amyloidosis, light chain proteins—which are a component of antibodies—mutate and build up in different organs. In new research published in The FEBS Journal, investigators have identified and characterized an antibody fragment that can bind to abnormal light chains to stabilize them and prevent their aggregation. The findings could have an important clinical impact because the current prognosis for individuals with light chain amyloidosis is extremely poor, and current treatments, Read More

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