Nf1 gene mutations disrupt brain cell plasticity and motor learning in mice

Nf1 mutation generates focal OPC hyperdensities. Immunohistochemistry of PDGFR? (green) revealed focal OPC hyperdensities (HD) in the OPC-specific Nf1-mutant mice (Nf1OPC-Het, or Nf1+/fl;Pdgfra::Cre). Scale bar, 1 mm. Representative non-HD (blue outline) and HD (yellow outline) OPCs (PDGFR?, green) are shown on the right. Scale bar, 20 µm. Credit: Pan et al Neurogenetic disorders, such as neurofibromatosis type 1 (NF1), are diseases caused by a defect in one or more genes, which can sometimes result in cognitive and motor impairments. Better understanding the neural underpinning of these disorders and how they Read More

Related posts:

  1. Understanding protein mutations that affect gene expression to promote cancer progression
  2. Study finds brain stores motor memories differently based on decision uncertainty
  3. Nanoscopic motor proteins in the brain build the physical structures of memory, study finds
  4. Study examines role of the gene TRPV4 in regulating perspiration in mice
  5. Research harnesses machine learning and imaging to give insight into stem cell behavior
  6. Neuroscientists map brain pathways for learning from negative feedback
  7. Brain neurotransmitter receptor antagonist found to prevent opioid addiction in mice
  8. ‘Time cells’ in the brain are critical for complex learning, study shows

Leave a Reply

Your email address will not be published. Required fields are marked *