Rare predicted loss-of-function variants, polygenic risk score linked to risk of A-fib

Rare predicted loss-of-function (pLOF) variants and a polygenic risk score (PRS) are associated with increased atrial fibrillation (AF) risk, according to a study published online June 26 in JAMA Cardiology. Oliver B. Vad, M.D., from Copenhagen University Hospital–Rigshospitalet in Denmark, and colleagues examined rare pLOF variants associated with AF and elucidated their role in risk of AF, cardiomyopathy, and heart failure in combination with a PRS in a genetic association and nested case-control study. Data were included for 403,990 individuals from the U.K. Biobank (median age, 58 years). Over a Read More

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