Researchers reveal neurons that regulate sensitivity to threat in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behavior in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD). The study, published in Current Biology, outlines how researchers at the Sainsbury Wellcome Center at UCL studied a region of the brain called the periaqueductal gray (PAG), which is known to be hyperactive in people with anxiety and PTSD. Their findings show that inhibitory neurons in the PAG constantly fire, which means that their Read More

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