by Xia & He Publishing Inc. Graphical abstract. Credit: Journal of Clinical and Translational Hepatology (2024). DOI: 10.14218/JCTH.2023.00446 Liver diseases are commonly diagnosed using serum enzyme assays, particularly for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and 5′-nucleotidase (5′-NT). While elevated levels of these enzymes are typically associated with liver and bile duct injuries, subnormal levels can also indicate various pathologies. A new review consolidates current knowledge on diseases linked with subnormal liver enzyme levels, focusing on their pathogenesis, specificity, and treatment implications. The study Read More