Graphical summary of a two-step spatiotemporal Tpex checkpoint by TCR engagement strength. Created with Biorender.com. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-024-01843-8 Immunotherapy, treatments that reinvigorate immune cells’ anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors. One reason for the stymied success is the conversion of potential cancer-killing T cells into an inactive “exhausted” state near the tumor. St. Jude Children’s Research Hospital scientists found that how tight a parental T cell grabs a cancer Read More