Scientists reveal how a potassium ion channel reprograms energy production in cancer cells

Characterization of BKCa channels in murine and human BCCs. Credit: eLife (2024). DOI: 10.7554/eLife.92511.3 Researchers have revealed how a channel that controls cellular potassium levels causes metabolic rewiring in breast cancer cells, promoting tumor growth. The study, published in eLife, was described by the editors as providing convincing evidence that an intracellular subpopulation of a specific potassium channel reprograms breast cancer cells towards the Warburg phenotype, one of the metabolic hallmarks of cancer. Ion channels are gateways within cells that tightly control the inward and outward flow of essential ions, Read More

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