Left, fluorescence image of amyloid in cryo-preserved post-mortem human brain. Middle, 3-dimensional molecular architecture of ?-amyloid plaque. Right, in-tissue structure of tau filaments within post-mortem brain. Credit: University of Leeds Scientists investigating Alzheimer’s disease have determined the structure of molecules within a human brain for the very first time. Published today in Nature, the study describes how scientists used cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer’s disease donor brain. This gave 3-dimensional maps in which they could observe proteins, the molecular building blocks of life Read More