No sex differences in protein levels of serine racemase in the mPFC were observed. Credit: Aging (2024). DOI: 10.18632/aging.205841 A new research paper titled “Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats” has been published in Aging. Aging is associated with a decrease in N-methyl-D-aspartate (NMDA) receptor function, which is critical for maintaining synaptic plasticity, learning, and memory. Activation of the NMDA receptor requires binding of the neurotransmitter glutamate and also the presence of co-agonist D-serine at the glycine site. Read More