Study reveals CREB3’s role in hepatocellular carcinoma suppression via AKT signaling

Expression of CREB3 is decreased in HCC tissues and correlated with better clinical outcome. (A) mRNA expression of CREB3 in HCC tissues and adjacent nontumor tissues. (B and C) mRNA and protein expression of CREB3 in indicated cell lines. CREB3-FL indicated the full length of CREB3; CREB3-N indicated N-terminus of CREB3. GAPDH as loading control. (D) Representative images and quantification of CREB3 IHC staining in 110 paired HCC tissues and adjacent nontumor tissues. Scale bar: 200 µm, 20 µm. (E) Relative expression scores of CREB3 in HCC with or without indicated clinicopathological Read More

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