Uncovering how cellular miscommunication leads to cognitive impairment in female patients with Alzheimer’s disease

Lead author Neta Rosenzweig, Ph.D., of the Brigham and Women’s Hospital Ann Romney Center for Neurological Diseases, and senior author Oleg Butovsky, Ph.D., of the Ann Romney Center and Gene Lay Institute of Immunology and Inflammation, share key messages from their paper titled “Sex-Dependent APOE4 Neutrophil-Microglia Interactions Drive Cognitive Impairment in Alzheimer’s Disease” published in Nature Medicine. How would you summarize your study for a lay audience? In this manuscript, we identify that a major genetic risk factor for the late onset of Alzheimer’s disease, APOE4, impairs the communication of Read More

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