Neutrophil (PMN) leukocytes participate to the initial phases of atherosclerosis through the release of Interleukin 8 (CxCL8; IL-8) that contribute to amplification of inflammation. Aim of the study is to investigate the production of IL-8 by PMN leukocytes from dyslipidemic patients treated with simvastatin.
Methods:
In 15 dyslipidemic subjects with moderately increased cardiovascular risk, assessed by Framingham Risk Score, blood samples were obtain to investigate PMNs IL-8 production [at baseline and after N-formyl-Met-Leu-Phe (fMLP) stimulation] before and after long-term (1-year) simvastatin treatment.
Results:
The resting release of IL-8 was higher in dyslipidemic patients at baseline when compared with control subjects (p
One year of treatment was significantly associated with reduced IL-8 production (p
IL-8 release after 1 year of treatment was reduced to levels which were lower than those observed in control subjects both for resting and stimulated cytokine production (p
Conclusions:
Prolonged treatment with simvastatin is associated with a reduction of IL-8 production, suggesting the possibility of statin to modulate the pro-inflammatory response in PMNs of patients with moderately increased cardiovascular risk.
Author: Franca MarinoAndrea Maria MarescaLuana CastiglioniMarco CosentinoRamona C MaioLaura SchembriCatherine KlersyChristian MongiardiLaura Robustelli TestAnna Maria GrandiLuigina Guasti
Credits/Source: BMC Cardiovascular Disorders 2014, 14:37
Published on: 2014-03-15
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