Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells


1 Samsung Genome Institute, Samsung Medical Center, Seoul, South Korea

2 Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, South Korea

3 Department of Urology, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea

4 Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea

5 Department of Anatomy and Cell Biology, Sungkyunkwan University, Seoul, South Korea

6 Department of Molecular Cell Biology, Sungkyunkwan University, Seoul, South Korea

7 Samsung Advanced Institute for Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, South Korea

8 Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea

9 Department of Biology, University of Pennsylvania, Philadelphia 19104, PA, USA

10 Penn Program in Single Cell Biology, University of Pennsylvania, Philadelphia 19104, PA, USA