healthmedicinet

Open, prospective, single-center study. All consecutive patients in whom treatment
with MER or TZP was indicated from October 2014 to March 2015 were included. A 2g
(MER) or 4g (TZP) loading dose was given followed by a 6g (MER) or 16-24g (TZP) continuous
infusion over 24 hours. Serum concentrations were determined by high-performance liquid
chromatography (HLPC) 1 hour, 24 hours and 3-5 days after the start of the infusion,
determining maximum (Cmax) and free steady state concentrations (Æ’Css). The objective
was maintaining Æ’Css 4-6 times above the MIC corresponding to the clinical breakpoint
for Pseudomonas aeruginosa from our hospital database: 8 µg/ml for MER and 16/4 µg/ml for TZP. When the target
was not achieved, the dose was adjusted.