(HealthDay)—For patients with coronary atheroma, high-intensity statin treatment is associated with greater regression in women than men, according to a study published online Sept. 17 in JACC: Cardiovascular Imaging.
Rishi Puri, M.B.B.S., from the Cleveland Clinic in Ohio, and colleagues examined sex-related differences in coronary atheroma regression after high-intensity statin treatment. Participants (765 men and 274 women) were treated with rosuvastatin 40 mg or atorvastatin 80 mg for 24 months.
The researchers found that women were older and more likely to have hypertension; diabetes; and higher low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and C-reactive protein (CRP) levels than men. Compared with men, at follow-up women had higher HDL-C (P
“Women with coronary disease demonstrate greater coronary atheroma regression than men when empirically prescribed guideline-driven potent statin therapy,†the authors write.
Several authors disclosed financial ties to pharmaceutical and biotechnology companies, including AstraZeneca, which sponsored the study.
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