Baseline characteristics, analysis plan and report on feasibility for the Prevention Of Decline in Cognition After Stroke Trial (PODCAST)

We thank all the patients, and their informants, for participating in the trial. We
also thank the funders: the Alzheimer’s Society and the Stroke Association. The sponsor
was the University of Nottingham. Finally, we thank the members of the independent
Data Monitoring Committee who supervised safety from the beginning to end of the trial.

Chief Investigator(s)

P. M. W. Bath (trial, and lipid arm), G. Ford (BP arm)

Trial Steering Committee

Independent members: John O’Brien (Chair, Newcastle/Cambridge), Stephen Ball (Leeds)

Grant holders: Philip M. W. Bath (Chief Investigator, Nottingham), Gary Ford (Co-Chief Investigator,
Newcastle/Oxford), Nikola Sprigg (Deputy Chief Investigator, Nottingham), Clive Ballard
(London), Alistair Burns (Manchester), Jonathan Mant (Cambridge), Peter Passmore (Belfast),
Stuart Pocock (Consultant Statistician, London), John Reckless (Bath), Rob Stewart
(London), Joanna M Wardlaw (Neuroradiologist, Edinburgh).

Patient Carer representatives: Dave Hanbury, John Murray, Shirley Nurock

Funders’ representative: Suzanne Sorensen (Alzheimer’s Society, ?2011), James Pickett (Alzheimer’s Society,
2011–), Peter Coleman (Stroke Association, 2010–14), Kate Holmes (2014–).

Sponsor representative: Angela Shone (University of Nottingham).

Independent Data Monitoring Committee

John Geddes (Oxford, Chair), Jan Staessen (Leuven), Chris Weir (Glasgow, Statistician).

Trial Management Committee

Trial Managers: S. Utton (?2014).

Assistant Trial Manager: H. Foster (2012–).

Medics: Sandeep Ankolekar (?2011), K. Krishnan (2012–).

Coordinators: L. Stokes (?2012), M. Mangoyana (2012–13), K. Whittamore (2013–14), M. Stringer (2014–).

Outcome Coordinators: J. Saunders (?2012), L. Wilkins (2011–12), L. Cobane (2012–13), J. Keeling (2013–).

Data managers: T. Jones (?2013), D. Hazle (2012–), M. Sampson (2013–).

Finance: W. Clarke.

Secretaries: Y. Smallwood, L. Dunn (2013–14).

Cognition/Dementia Adjudicators:

Alistair Burns (Chair, Manchester), Clive Ballard (London), Gary Ford (Newcastle).

Vascular Events Adjudicators:

Peter Passmore (Chair, Belfast), Amit Mistri (Leicester, 2013–14), Robert Henderson
(Nottingham, 2013–14).

Serious Adverse Events Adjudicators

Tim England (Derby).

Neuroimaging Adjudicators

Joanna M. Wardlaw (Chair, Edinburgh), Dan Blackburn (Sheffield, 2014).

Health economics

Paul McCrone (London), Martin Knapp (London)

Statistical Analysis

L. Fox (2012–13), P. Scutt (2013–), Lisa Woodhouse (2014–).

Data Management and Programming

Liz Walker, L. Haywood (2011–), Richard Dooley (2013–14)

Recruiting sites (patients recruited/screened): PI, Investigators

Aberdeen Royal Infirmary (6/14): Dr M. J. MacLeod, A. Joyson, H. Gow, J. Furnace

Aintree Hospitals NHS Foundation Trust (5/9): Dr R. Durairaj, C. Cullen, D. Dickinson,
M. Ashkar, T. Ingram, V. Sutton, Z. Mellor

Birmingham, Heart of England NHS Foundation Trust – Solihull Hospital (2/9): Dr K.
Elfandi, U. Kahn, S. Stafford

Bournemouth, Royal Christchurch Hospitals NHS Foundation Trust. (6/14): Dr D. Tiwari,
A. Orpen, B. Longland, C. Ovington, E. Rogers, G. Hann, J. Bell, J. Kwan

Bradford Teaching Hospitals NHS Foundation Trust (1/5): Dr C. Patterson, B. Hairsine,
L. Johnston, R. Bellfield

Chesterfield Royal Hospital NHS Foundation Trust (2/9): Dr M. Sajid, M. Ball

Cornwall, Royal Hospitals NHS Trust, Truro (9/17): Dr F. Harrington, A. Mate, C. Schofield,
G. Courtauld, M. Drake

Doncaster Bassetlaw Hospitals NHS Foundation Trust (1/2): Dr M. Kini, D. Walstow,
M. Hanna

Inverness, Raigmore Hospital (1/3): Dr P. F. Findlay, A. Macaden, I. Shread

Margate, QEQM Hospital (1/1): Dr G. Thomas, S. A. Jones

Mid Cheshire Hospitals NHS Foundation Trust (3/10): Dr A. Kalathil, N. Gautam, R.
Miller

Newcastle-upon-Tyne Hospitals NHS Foundation Trust (6/15): Dr S. Louw, A. Barkat,
G. Kennedy, M. Fawcett, T. Thompson, V. Hogg

North Tees Hartlepool NHS Foundation Trust (2/4): Dr B. Kumar, D. Bruce, M. Platton

Nottingham University Hospitals NHS Trust (22/27): Dr A. K. Shetty, Prof P. Bath,
Dr K. Krishnan, F. Shelton, J. Clarke, L. Wilkins, Z. Rose, K. Whittamore

Scarborough General Hospital (1/1): Dr J. Paterson, K. Deighton

South Tyneside NHS Foundation Trust (1/4): Dr J. Scott, J. Graham, M. Duffy

West Cumberland Hospital, Whitehaven (1/1): Dr E. Orugun, H. Crowther, R. Jolly

Yeovil District Hospital NHS Foundation Trust (3/17): Dr K. Rashed, C. Buckley, C.
Vickers, D. Hayward, E. Keeling, S. Board

York Hospitals NHS Foundation Trust (10/11): Dr J. Coyle, A-M Porteous, M. Keeling,
N. Dyer, P. Willcoxson

Sites that screened but did not recruit:

Bath, Royal United Hospital NHS Trust (4): Dr J. Reckless, B. Madigan, D. Button

Derby Hospitals NHS Foundation Trust (1): Dr K. Muhiddin, M. Mangoyana

Leicester, University Hospitals (2): Dr D. Eveson, S. Khan

Poole Hospital NHS Foundation Trust (7): Dr S. Ragab, C. Dickson

South Tees Hospitals NHS Foundation Trust (2): Dr D. Broughton, K. Chapman