The Serum Cytokines’ Network and Th1/Th2 Profile Balance in patients with Chronic Urticaria

This prospective study included 46 patients with CU and 12 patients without urticaria
or angioedema as a control group. Patients diagnosed with CU were separated to two
subgroups with and without atopy (14/32). These patients were randomly selected at
the Center of Asthma, Allergy and Clinical Immunology at TSMU. In peripheral blood
was detected T CD4+, CD8+lymphocytes by flow cytometry using Becton Dikinson’s monoclonal
antibodies. The serum levels of IgE (total), sIL-2R, IL-6, IFN-?, TNF-?, IL-4, IL-5,
IL10, IL-13 were measured using ELISA, RD System kits, Germany, at the lab of Immunology
and Microbiology at TSU.