Cardiovascular effects and tolerance of adenosine versus regadenoson during cardiac MRI perfusion testing

We performed a prospective non-randomized controlled trial of 25 healthy volunteers
undergoing stress CMR. Vital signs, ventricular volumes, pulmonic and aortic flow
were measured at baseline and immediately following infusion of adenosine (140mcg/kg/min
IV for 6 minutes) and at 5, 10, and 15 minutes after infusion utilizing a 1.5T MRI
Scanner (Siemens Espree) and 32 channel coil (Siemens Tim). Following a 10 minute
rest period the same protocol was performed utilizing a standard dose of regadenoson
(0.4mg IV over 10 seconds). A survey of side effects, medication tolerance and drug
preference was given at the end of exam. All measurements were performed utilizing
QMass (Vital Imaging, 2014).