Bowel cancer turns genetic switches on and off to outwit the immune system, new study finds

Frameshift switching of the MSH6 C8 coding homopolymer drives stochastic loss and restoration of MSH6 expression like a molecular ON/OFF switch. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01777-9 Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that’s been observed for the first time by researchers at UCL and University Medical Center Utrecht. The number of genetic mutations in a cancer cell was previously thought to be purely down to chance. But a new study, published in Read More

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