Study identifies epigenetic ‘switches’ that regulate the developmental trajectories of single cells

Analysis of the developmental cell atlas. a, Workflow to obtain single-cell RNA (scRNA) expression and CUT&Tag data for three histone modifications (H3K27me3, H3K4me3 and H3K27ac). b, Using MCMF bipartite matching and Cellrank2, we derived multi-omic metacells and constructed a force-directed layout that shows the developmental trajectories from the neuroepithelium into the major brain regions and cellular differentiation states. RNA expression and histone modification enrichment throughout the developmental time course at NEUROD2. PSC, pluripotent stem cell; NPC, neural precursor cell. Credit: Zenk et al Individual cells in the human body develop Read More

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