Deletion of A2B receptors in hippocampal astrocytes. Credit: Nature (2024). DOI: 10.1038/s41586-024-07611-w A key mechanism which detects when the brain needs an additional energy boost to support its activity has been identified in a study in mice and cells led by UCL scientists. The scientists say their findings, published in Nature, could inform new therapies to maintain brain health and longevity, as other studies have found that brain energy metabolism can become impaired late in life and contribute to cognitive decline and the development of neurodegenerative disease. Lead author Professor Read More