Migraine pain caused by lack of lymphatic system drainage in brain, study suggests

Credit: Journal of Clinical Investigation (2024). DOI: 10.1172/JCI175616 Migraine is a chronic and debilitating neurological condition affecting women 3 to 4 more times than men. Despite an estimated 1.1 billion people being impacted by the condition, the physiological underpinnings of migraine remain mysterious, but are highly studied. For the first time, researchers from the UNC School of Medicine’s Department of Cell Biology and Physiology have pieced together how a small protein called calcitonin gene-related peptide (CGRP) influences the lymphatic vascular system, contributing to the pain during migraine attacks. Their results Read More

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