Structural modeling shows the crystal structure of homodimeric HNF4A (upstream subunit in green, downstream subunit in cyan) bound to its DNA response element (orange), coactivator peptides (salmon and white) and myristoate (PDB code 4IQR) (left), and the final trajectory structure from a representative molecular dynamics (MD) simulation of phosphorylated HNF4A complexed with DNA (right). Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-48647-w Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Read More