Neurons express Aplp1 (in white), a key protein that allows brain cells to absorb Parkinson’s-disease causing alpha-synuclein. Credit: Yasuyoshi Kimura, Ph.D. In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson’s disease-causing alpha-synuclein. The findings, published May 31 in Nature Communications, reveal how Aplp1 connects with Lag3, another cell surface receptor, in a key part of a process that helps spread harmful alpha-synuclein proteins to brain cells. Those protein Read More