Protein droplets likely don’t cause Parkinson’s, study suggests

Credit: Advanced Science (2024). DOI: 10.1002/advs.202308279 Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson’s disease, shows a recent study. Rather, the formation of protein into liquid droplets may help to dissolve aggregated protein. The study, published in the journal Advanced Science, deepens our understanding of neurodegenerative diseases linked to protein aggregation and could help develop new therapies. Add vinegar to oil and shake: droplets of oil form. The concept of liquid-liquid phase separation has been known in everyday life for generations, Read More

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