During osteoclast differentiation, Ctdnep1 expression remains consistent, yet its depletion results in heightened osteoclast formation and activity. Mechanistically, Ctdnep1 demonstrates a suppressive effect on the RANKL signaling pathway, suggesting its role as a negative regulator in osteoclast differentiation. Credit: Professor Tadayoshi Hayata from Tokyo University of Science Osteoporosis, a condition characterized by porous and fragile bones, poses a significant threat to skeletal health. As the very framework of the human body, bones provide crucial structural support. When bone mass diminishes, it not only compromises this support but also impairs overall Read More