The team used ancestral sequence reconstruction to study ancient TRPM8 proteins, providing new avenues for pain relief without adverse effects seen in previous TRPM8-targeted treatments. This research exemplifies how evolutionary biology and modern pharmacology can collaborate to improve chronic pain management. Credit: ASU/ Wade Van Horn Chronic pain affects millions worldwide, and current treatments often rely on opioids, which carry risks of addiction and overdose. Non-addictive alternatives could revolutionize pain management, and new research targeting the human protein which regulates cold sensations, brings scientists closer to developing pain medications that Read More