Study suggests that adding common bone loss drugs to azoles can improve efficacy when treating fungal infections

Combining ketoconazole and zoledronate prevents the development of antifungal resistance in T. rubrum. Credit: mSphere(2024), DOI: 10.1128/msphere.00248-24 Human skin, hair and nails are all vulnerable to fungal infections. While these infections are usually not serious, they’re difficult to fully resolve and often recur after treatment—sometimes for years. They’re also often resistant to treatments, including a common class of antifungals called azoles. A study published in mSphere points to a new way to boost the efficacy of azoles in treating those infections—combining them with commonly available drugs called bisphosphonates, usually used Read More

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