TCF1-deficiency attenuated pathogenicity of CD4+ T cells. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-024-01860-7 Scientists at La Jolla Institute for Immunology (LJI) have shed light on how an unusual population of T cells may drive harmful inflammation in people with ulcerative colitis, an autoimmune disease that causes damage to the large intestine. Their new study, published recently in Nature Immunology, is the first to show a link between “stem-like” T cells and ulcerative colitis in human patients. “We’ve found a population of T cells that may be important in disease—and may Read More