SSCs are heterogeneous in nature, contributing to the development of long bones, craniofacial structures, and the spine. These SSCs have important functions in a variety of physiological and pathological processes, which are determined by their precise anatomical locations. Credit: Protein & Cell (2024). DOI: 10.1093/procel/pwae008 Skeletal stem cells (SSCs) are essential for bone development, homeostasis, and repair. Recent studies have identified distinct SSC populations in long bones, craniofacial bones, and spine. Techniques like single-cell sequencing have mapped SSC lineage commitment trajectories. SSCs also play roles in bone repair and diseases. Read More