RIP3 plays a pivotal role in the pathogenesis of OA by disrupting cartilage extracellular matrix (ECM) metabolism homeostasis, inhibiting bone formation, and enhancing bone resorption, while clofibrate appears to be a promising drug against OA by targeting RIP3. Credit: Science China Press Osteoarthritis (OA) represents the most prevalent form of chronic degenerative joint disease worldwide. The dynamic interplay between cartilage and subchondral bone is essential for preserving joint structural and functional integrity. In addition to cartilage degeneration, pathological alterations within the subchondral bone significantly contribute to OA progression. Therefore, there Read More