Study uncovers multiple molecular subgroups in liver cancer with most aggressive driving clinical outcomes

Credit: Journal of Hepatology (2024). DOI: 10.1016/j.jhep.2024.05.017 A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR’s Genome Institute of Singapore (GIS) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of hepatocellular carcinoma (HCC) cases harbor more than one molecular subtype within the same tumor, and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype. This phenomenon, termed the “bad apple effect,” has significant implications on the understanding of liver cancer Read More

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