Activating a molecular target reverses multiple hallmarks of aging, new study demonstrates

Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.05.048 Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring “youthful” levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models. If these findings are confirmed in clinical studies, there may be therapeutic implications for age-related diseases such as Alzheimer’s, Parkinson’s, heart disease and cancer. The study, published today in Cell, identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), which normally Read More

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