Intestinal organoids, a bright field image on the left and a fluorescence image on the right. Organoids are tissue cultures initiated from intestinal stem cells isolated from a patient’s intestinal biopsy. In organoids, the different cell types of the intestinal surface epithelium organize themselves as in real intestinal tissue. These mini-intestines can be grown practically indefinitely and used to model the inflammatory response of celiac disease by administering inflammatory mediators. The fluorescence image features one of the proteins (pink) under scrutiny, which reacts to inflammation in the nuclei of the Read More