Cortical network excitability shows significant dynamic alterations in PRG-1R345T/WT mutation carriers. Credit: Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02598-2 A genetic disorder leads to an increase in bioactive lipids in the brain, resulting in an imbalance between excitation and inhibition in neural circuits and promoting mental disorders. However, treatment with an enzyme inhibitor that prevents the activation of lipids can restore balance and alleviate symptoms. Increased levels of bioactive lipids produced naturally in the body, which affect excitatory transmission between brain cells, promote mental disorders. However, this mechanism can be rebalanced by Read More