Cells with cancer-causing p53 proteins (red); the genetic material in the cell nuclei is in blue. Left: In the presence of a regular DNAJA2 chaperone, the structure of the p53 proteins is stabilized, so they do not bind with one another and therefore remain scattered throughout the cell. Right: In contrast, in the presence of a DNAJA2 variant without a “hairpin,” the cancer-causing p53 proteins form clusters (red dots) that the cell can recognize and destroy. Credit: Weizmann Institute of Science “Who will watch the watchers?” asked Roman poet Juvenal Read More