Immunostaining images showing differential PK sensitivity of tau aggregates in brain homogenates from IgG-ms- and TTCM2-ms–treated mice. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adj5958 A multi-institutional team of neuroscientists has developed a nasal therapy that cleared the brains of Alzheimer’s mouse models of toxic tau proteins. In their study, published in the journal Science Translational Medicine, the group found a certain conformation-specific antibody that would bind to tau proteins, placed it inside of a shell that allowed it to travel through the blood brain barrier, and then tested it with Read More