PVHSH2B1?DRN neurocircuit inhibits food intake and obesity. Credit: Advanced Science (2024). DOI: 10.1002/advs.202400437 Obesity is a complicated condition, caused by a combination of genetics, the food environment, behavior, and other factors. For millennia, getting enough food to survive and thrive was difficult. For most people, it’s now as easy as opening a refrigerator. A gene called SH2B1 has been shown to play an important role in regulating food intake. SH2B1 mutations in people are associated with obesity, type 2 diabetes and metabolic dysfunction-associated steatotic liver disease, formerly known as non-alcoholic Read More